GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11758351 | 1 | rs1341759 | chr6:26195502 | HIST1H3E | chr6:26224427-26226589:+ | 0.35 | 6.74 | 2.58E-11 | Renal underexcretion gout;Gout |
| BRCA | cis | rs4665058 | 1 | rs13421084 | chr2:160086468 | WDSUB1 | chr2:160092305-160143236:- | 0.29 | 3.69 | 0.000237 | Sudden cardiac arrest |
| BRCA | cis | rs9309473 | 1 | rs13421462 | chr2:73719875 | ALMS1P | chr2:73872046-73912692:+ | 0.27 | 6.7 | 3.41E-11 | Metabolite levels |
| BRCA | cis | rs13424612 | 1 | rs13424612 | chr2:240900121 | NDUFA10 | chr2:240900158-240964798:- | 0.27 | 7.09 | 2.41E-12 | Odorant perception (isobutyraldehyde) |
| BRCA | cis | rs4665058 | 1 | rs13429638 | chr2:160095145 | WDSUB1 | chr2:160092305-160143236:- | 0.36 | 4.4 | 1.17E-5 | Sudden cardiac arrest |
| BRCA | cis | rs6708331 | 1 | rs13429940 | chr2:70379868 | FAM136A | chr2:70523109-70529220:- | -0.11 | -3.59 | 0.000343 | Obesity-related traits |
| BRCA | cis | rs4665058 | 1 | rs13431025 | chr2:160092405 | WDSUB1 | chr2:160092305-160143236:- | 0.34 | 4.2 | 2.91E-5 | Sudden cardiac arrest |
| BRCA | cis | rs25422 | 1 | rs13437605 | chr6:118899014 | C6orf204 | chr6:118786239-119031238:- | -0.11 | -3.47 | 0.000534 | Renal cell carcinoma |
| BRCA | cis | rs3796352 | 1 | rs1346719 | chr3:53077372 | NT5DC2 | chr3:52558386-52569093:- | -0.14 | -3.5 | 0.000478 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs3796352 | 1 | rs1346719 | chr3:53077372 | RFT1 | chr3:53122503-53164470:- | 0.2 | 3.44 | 0.000611 | Immune reponse to smallpox (secreted IL-2) |
| BRCA | cis | rs1949733 | 1 | rs1357481 | chr4:8496221 | C4orf23 | chr4:8440604-8495258:+ | -0.15 | -3.94 | 8.61E-5 | Response to antineoplastic agents |
| BRCA | cis | rs10935120 | 1 | rs1357762 | chr3:134264859 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 13.43 | 3.94E-38 | Height |
| BRCA | cis | rs10935120 | 1 | rs1357762 | chr3:134264859 | CEP63 | chr3:134204575-134293852:+ | 0.15 | 3.98 | 7.5E-5 | Height |
| BRCA | cis | rs1359582 | 1 | rs1359582 | chr10:90330483 | LIPF | chr10:90424094-90438572:+ | 0.13 | 3.39 | 0.000713 | Depressive and manic episodes in bipolar disorder |
| BRCA | cis | rs1364989 | 1 | rs1364989 | chr4:55011769 | FIP1L1 | chr4:54243820-54326102:+ | 0.17 | 4.09 | 4.71E-5 | Lupus nephritis in systemic lupus erythematosus |